Journal: Journal of Antimicrobial Chemotherapy

Article Title: Antibiotic prescribing for common infections in UK general practice: variability and drivers

doi: 10.1093/jac/dkz163

Figure Lengend Snippet: Percentage of patients receiving an antibiotic for each common infection stratified by age and sex (based on fractional polynomials in logistic models). Dashed lines represent 95% CI.

Article Snippet: To account for non-linear associations, age was transformed using the multiple fractional polynomials (mfp) package in RStudio (R; version 3.3.3).

Techniques: Infection

Journal: BMC Medicine

Article Title: Antenatal iron supplementation and birth weight in conditions of high exposure to infectious diseases

doi: 10.1186/s12916-019-1375-9

Figure Lengend Snippet: Effect of antenatal iron supplementation on neonatal birth weight in Kenya, by iron status at baseline. Iron status is indicated by body iron index, i.e. the natural logarithm of the ratio of plasma concentrations of ferritin (μg/L) and soluble transferrin receptor (mg/L), both adjusted for inflammation and Plasmodium infection (see text). Effects were adjusted for HIV infection and parity; other covariates were eliminated in the multiple fractional polynomial regression ( mfpi) procedure. Based on analysis of 391 Kenyan women. Left panel : Associations between birth weight and body iron index for women who received supplementation with iron (blue line) or placebo (red line). The difference between these lines is the treatment effect (i.e. the difference in mean birth weight between the iron group and the placebo group, with the placebo group used as the reference) conditional to body iron index. The cumulative relative frequency distribution of the body iron index is indicated by the grey line (and right Y -axis); 95% of women had values in the range between − 0.55 and 2.82. Right panels : treatment effect as a function of body iron index, with corresponding 95% confidence bands and p value for interaction. The horizontal solid line indicates zero effect, whilst the horizontal dashed line indicates the intervention effect as measured in a regression model without covariates other than the intervention (140 g)

Article Snippet: Effects were adjusted for HIV infection and parity; other covariates were eliminated in the multiple fractional polynomial regression ( mfpi) procedure.

Techniques: Clinical Proteomics, Infection

Journal: BMC Cancer

Article Title: A lack of association between BMI and chemoimmunotherapy efficacy in advanced non-small cell lung cancer: Secondary analysis of the IMpower150 and IMpower130 clinical trials

doi: 10.1186/s12885-024-12132-w

Figure Lengend Snippet: Treatment effect estimates (chemoimmunotherapy versus chemotherapy) with continuous BMI by the method of Multivariate Fractional Polynomial Interaction with Cox proportional-hazard regression models stratified by trial for overall survival ( a ) and progression-free survival ( b ). The shaded area is the 95% CIs of the treatment effect estimated as hazard ratios (HRs) (black solid line). Vertical dotted lines mark the 5 th and 95 th percentile of BMI distribution of the pooled analysis cohort, at 19.8 kg/m 2 and 34.7 kg/m 2 respectively

Article Snippet: Continuous BMI was modelled in stratified (by RCT) Cox proportional hazards regression by the method of (Multivariable) Fractional Polynomial Interaction (MFPI) [ ].

Techniques: